Effects of Mosapride Citrate on Human Plasma Levels of Motilin, Gastrin, Somatostatin, and Secretin
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概要
- 論文の詳細を見る
The effect of mosapride citrate(mosapride)on plasma levels of gastrointestinal peptides(motilin, gastrin, somatostatin, and secretin)was studied in five healthy volunteers. After a single oral administration of mosapride(15mg), the plasma mosapride level(85.0±13.7ng/ml)was highest in the 60-min sample after the administration and then the plasma level fell. Peak plasma motilin levels(18.6±1.7pg/ml)were acheived 60 min after administration of mosapride(p<0.01 vs.placebo), and returned to baseline levels within a further 120min. Plasma gastrin levels(42.4±3.6pg/ml)increased 60 min after administration of mosapride(p<0.01 vs.placebo). Plasma somatostatin and secretin levels did not change significantly. These results suggest that the pharmacological effects of mosapride on gastrointestinal functions are closely related to changes in motilin-immunoreactive substance levels in human plasma.
- 公益社団法人日本薬学会の論文
- 2001-09-01
著者
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Takeyama M
Oita Univ. Hospital
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NAGANO TOSHIAKI
Department of Clinical Pharmacy, Oita Medical University
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Itoh Hiroki
大分大学医学部附属病院 薬剤部
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