Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans
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概要
- 論文の詳細を見る
Rabeprazole sodium (rabeprazole), a proton pump inhibitor (PPI), is widely used in the treatment of peptic ulcer and gastroesophageal reflux disease. Recently, some antiulcer medicines have been elucidated pharmacologically from the viewpoint of gut-regulated hormone levels. We examined the effects of rabeprazole on plasma levels of gastrointestinal peptides [gastrin, somatostatin, motilin, substance P, and calcitonin generelated peptide (CGRP)]. Rabeprazole at a dose of 20mg or placebo was orally administered to 5 healthy male volunteers aged 25-30 years. Venous blood samples were taken before and 30, 60, 90, 120, 180, 240, and 360min after administration. Plasma peptide levels were measured using a sensitive enzyme immunoassay. Compared with the response of the placebo group, rabeprazole caused significant (p<0.05) increases in gastrin-, somatostatin-, and CGRP-like immunoreactive substance (IS) at 360, 180, and 240min, respectively. Rabeprazole significantly decreased motilin-IS levels at 180min compared with the placebo group. However, rabeprazole had no effect on plasma substance P-IS levels. Although rabeprazole has potent antisecretry effects, the agent may have little effect on gastrointestinal peptides.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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SATO Yuhki
Department of Clinical Pharmacy, Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Takeyama M
Oita Univ. Hospital
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Sato Yuhki
Department Of Clinical Pharmacy Oita University Hospital
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences
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