Monitoring Plasma Neuropeptide-Like Immunoreactivity Levels in a Patient Given Hange-koboku-to for a Week for Swallowing Reflex Disorder
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概要
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Hange-koboku-to (Banxia-houpo-tang), a Traditional Chinese Medicine remedy, has been used to treat swallowing reflex disorder, and it has been recently suggested that one of the mechanisms for the empirical effect of Hange-koboku-to involves humoral changes in neuropeptide levels. We suggested to administer Hange-koboku-to to a 70-year-old man with swallowing reflex disorder due to multiple cerebral infarctions and investigated the relationship between changes in plasma neuropeptide-like immunoactivity (LI) levels and swallowing for a period of 1 week. On the 4th and 7th day of administration, the patient's plasma calcitonin gene-related peptide (CGRP)-LI levels were twice the concentration on day 0 and Hange-koboku-to had increased the patient's plasma substance P-LI levels approximately 5-fold on these 2 days. The plasma substance P-LI levels on days 4 and 7 were close to the levels (mean±SD) of elderly subjects without swallowing reflex disorder. Following the administration of Hange-koboku-to, plasma somatostatin-LI and vasoactive intestinal polypeptide (VIP)-LI levels in this patient exceeded those of elderly subjects without swallowing reflex disorder (mean±SD). With regard to symptoms, the patient's difficulty in swallowing had disappeared on the third day of administration. This study suggests that Hange-koboku-to relieves swallowing reflex disorder by stimulating neuropeptidergic nerves and that this effect is achieved within 1 week of administration. However, we need to study more cases of the use of Hange-koboku-to for swallowing reflex disorder and further investigate the relationship between changes in neuropeptide-LI levels and its pharmacological effects.
- 日本医療薬学会の論文
- 2005-07-10
著者
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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HASHIMOTO Hisakuni
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Naito Takafumi
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Takeyama M
Oita Univ. Hospital
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences
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