Lafutidine Changes Levels of Somatostatin, Calcitonin Gene-Related Peptide, and Secretin in Human Plasma
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概要
- 論文の詳細を見る
We examined the effects of the histamine H_2-receptor antagonist, lafutidine, on the levels of gastrointestinal peptides (somatostatin, calcitonin gene-related peptide (CGRP), gastrin, secretin, and motilin) in plasma from healthy subjects. After a single oral administration of lafutidine (10mg), the plasma lafutidine level (186± 13.4ng/ml) was highest in the 60-min sample after administration and then the plasma level fell. Lafutidine caused significant increase in plasma somatostatin levels at 20 to 120min and in CGRP levels at 40 to 120min, compared with a placebo group. The physiological release of plasma secretin was reduced by administration of lafutidine, but the medicine did not alter the level of gastrin or motilin. These results suggest that the pharmacological effects of lafutidine on regulation of gastrointestinal functions closely relate to changes of somatostatin-, CGRP-and secretin-immunoreactive substance levels in human plasma.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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NAITO Takafumi
Department of Clinical Pharmacy, Oita Medical University
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Takeyama M
Oita Univ. Hospital
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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