Effect of Dai-kenchu-to on Levels of 3 Brain-gut Peptides (Motilin, Gastrin and Somatostatin) in Human Plasma
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概要
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We examined the effect of Dai-kenchu-to (DKCT), a traditional Chinese (Kampo) medicine, on the levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in plasma from 24 healthy subhects. A single oral administration of DKCT, at a dose of 7.5 g, caused significant increases in plasma motilin levels (about 12 pg/ml) at 60 to 90 min, compared with a placebo-treated group. Transient elevations of gastrin levels were noted after administration of both DKCT (25.9±1.4 pg/ml) and placebo (23.5±1.3 pg/ml). DKCT did not alter the levels (about 5.7 pg/ml) of somatostatin. In conclusion, these results indicate that the action of DKCT closely relates to changes in motilin-immunoreactive substance levels in human plasma.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Takeyama M
Oita Univ. Hospital
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NAGANO TOSHIAKI
Department of Clinical Pharmacy, Oita Medical University
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Itoh Hiroki
大分大学医学部附属病院 薬剤部
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