Determination of Granisetron in Human Plasma by High-performance Liquid Chromatography
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概要
- 論文の詳細を見る
A simplified procedure was developed for the determination of granisetron (GRN), a selective 5-HT_3 receptor antagonist, in human plasma by high-performance liquid chromatography. The procedure involves elution of GRN from plasma by solid-phase extraction prior to reversed-phase chromatographic separation on a cyano propyl silica column with subsequent quantification with a fluorescence detector. Using I ml of plasma sample, Iinear responses in concentration-peak area ratios were observed to range from 0.l to 25.0 ng/ml plasma. The coefficient of variance value of the measurement was below 5 % across the calibration range, and the recovery of GRN from plasma reached 98%. The assay method was applied to determine the plasma level of GRN in healthy adults after a single oral administration (2 mg), followed by analysis according to a 2-compartment open model employing first-order absorption. This method was found to be useful to support drug monitoring and . studies for GRN.
- 日本医療薬学会の論文
- 1997-02-10
著者
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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MORIKAWA Norifumi
Department of Clinical Pharmacotherapy, Division of Clinical Pharmacotherapeutics, Graduate School o
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Takeyama M
Oita Univ. Hospital
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NAGANO TOSHIAKI
Department of Clinical Pharmacy, Oita Medical University
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Morikawa Norifumi
Department Of Clinical Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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Morikawa N
Department Of Clinical Pharmacotherapy Hiroshima University
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Hiroshima University
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Division Of Clinical Pharmacotherapeutics Graduate School Of
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