Evaluation of Clonazepam Pharmacokinetics in Epileptic Children Receiving Monotherapy or Polytherapy, and the Influences of Concomitant Antiepileptic Drugs on the Serum Concentration of Clonazepam
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the relationship between the steady-state serum concentration of clonazepam and the daily dose per weight in epileptic children under 12 years of age who were receiving chronic monotherapy or polytherapy. We also examined the effects of the concurrent adrministration of other antiepileptic drugs, including phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ), zonisamide (ZNS), and valproic acid (VPA), on the serum concentration of clonazepam by multiple linear regression analysis. The clonazepam concentration in the same daily dose and the concentration/dose ratio were lower in the polytherapy group than in the monotherapy group. The clonazepam concentration was noted to be positively proportional to the dose of clonazepam and was negatively affected by the addition of PB, PHT, and CBZ, but not of ZNS or VPA. The present results suggest that the differences of clonazepam pharmacokinetics in the monotherapy and polytherapy are associated with the effects of PB, PHT, and CBZ on the serum concentration of clonazepam.
- 日本医療薬学会の論文
- 1998-04-10
著者
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Eshima Nobuoki
Department of Medical Information Analysis, Oita Medical University
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Izumi Tatsuro
Department Of Brain And Nerve Science Division Of Pediatrics And Child Neurology Oita University Fac
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Izumi Tatsuro
Department Of Pediatrics Oita Medical University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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Eshima Nobuoki
Department Of Medical Information Analysis Oita Medical University
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Eshima Nobuoki
Department Of Human Environmental And Social Medicine Oita Medical University
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MORIKAWA Norifumi
Department of Clinical Pharmacotherapy, Division of Clinical Pharmacotherapeutics, Graduate School o
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Takeyama M
Oita Univ. Hospital
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Izumi Tatsuro
Department Of Brain And Nerve Science Department Of Pediatrics Oita University Faculty Of Medicine
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Morikawa Norifumi
Department Of Clinical Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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Morikawa N
Department Of Clinical Pharmacotherapy Hiroshima University
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Hiroshima University
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Division Of Clinical Pharmacotherapeutics Graduate School Of
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