Effects of Pirenzepine on Dai-kenchu-to-Induced Elevation of the Plasma Neuropeptide Levels in Humans(Pharmacology)
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概要
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Dai-kenchu-to has been used for the treatment of abdominal obstructions, including bowel obstructions and a feeling of coldness in the abdomen. We reported that Dai-kenchu-to increases plasma neuropeptide [motilin, vasoactive intestinal polypeptide (VIP), serotonin, calcitonin gene-related peptide (CGRP), and substance P]-like immunoreactive substances (IS) levels and that its pharmacologic effects on the gastrointestine are due to changes in gastrointestinal mucosa-regulatory peptide levels. We examined the effects of the selective M_1 muscarinic receptor antagonist pirenzepine on the elevation of Dai-kenchu-to-induced plasma neuropeptide (gastrin, motilin, somatostatin, VIP, CGRP, substance P)-IS levels in human volunteers and the area under the plasma neuropeptide concentration-time curve from 0 to 240min (AUC_<0→240min>), which were calculated from the plasma neuropeptide concentration-time curves from each volunteers. Oral pretreatment with pirenzepine reduced the Dai-kenchu-to-induced elevation of plasma motilin and VIP-IS levels and AUC_<0→240min>. Combined treatment with Dai-kenchu-to and pirenzepine increased plasma somatostatin-IS levels and decreased plasma gastrin-IS levels and had no effects on plasma CGRP- and substance P-IS levels and AUC_<0→240min> compared with administration of Dai-kenchu-to alone. Dai-kenchu-to appeared to induce the release of motilin and VIP into plasma mainly through the activation of M_1 muscarinic receptors, and pirenzepine may affect the pharmacologic action of Dai-kenchu-to by elevation of plasma motilin and VIP levels.
- 2006-01-01
著者
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Inoue Shin
Department of Internal Medicine, Showa University Dental Hospital
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Inoue S
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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SATO Yuhki
Department of Clinical Pharmacy, Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Takeyama M
Oita Univ. Hospital
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Sato Yuhki
Department Of Clinical Pharmacy Oita University Hospital
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Inoue Shin
Department Of Clinical Pharmacy Oita University Hospital
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Inoue S
Fujisawa Technical Serv. Co. Ltd. Osaka Jpn
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences
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