Effects of Some Kampo Medicines on Plasma Levels of Neuropeptide Y under Venipuncture Stress(Pharmacology)
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概要
- 論文の詳細を見る
Some traditional Chinese herbal (Kampo) medicines have recently been evaluated for their clinical usefulness in stress and depression. These medicines have modulatory effects on the hypothalamic-pituitary-adrenal axis and sympathetic nervous system (SNS). We examined the effects of Rikkunshi-to, Hange-shashin-to, Hange-koboku-to, and Ninjin-to on plasma levels of neuropeptide Y (NPY), which is the representative neurotransmitter of the SNS, under venipuncture stress. Rikkunshi-to and Hange-shashin-to suppressed increases in plasma NPY-immunoreactive substance levels compared with the response to a placebo. In this study, Rikkunshi-to and Hange-shashin-to altered plasma levels of NPY under venipuncture stress. These effects might be benefical in stress-related diseases and our results suggest that these medicines have clinical pharmacologic activity.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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SATO Yuhki
Department of Clinical Pharmacy, Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Takeyama M
Oita Univ. Hospital
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Sato Yuhki
Department Of Clinical Pharmacy Oita University Hospital
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences
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