Effects of Domperidone on Human Plasma Levels of Motilin, Somatostatin, Gastrin, Adrenocorticotropic Hormone and Cortisol(Pharmacology)
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概要
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Domperidone, an upper gastrointestinal function regulatory medicine, has recently been evaluated for its clinical usefulness in the treatment of stress and depression. We examined the effects of domperidone on the plasma levels of motilin-immunoreactive substance (IS), somatostatin-IS, gastrin-IS, adrenocorticotropic hormone (ACTH)-IS, and cortisol under stress conditions by repetitive blood sampling. After a single oral administration of domperidone (30mg), the plasma domperidone level was highest (58.6±6.4ng/ml) in the sample taken 40min after administration, after which the plasma level fell. Peak plasma motilin-IS levels (23.1±1.4pg/ml) were achieved 40min after administration of domperidone (p<0.01vs. placebo), and returned to baseline levels within a further 40min. Plasma somatostatin-IS levels (13.0±1.2pg/ml) increased 60min after administration of domperidone (p<0.01 vs. placebo). Plasma gastrin-IS levels did not change significantly. These results suggest that the pharmacological effects of domperidone on gastrointestinal functions are closely related to changes in motilin-IS and somatostatin-IS levels. Domperidone significantly suppressed increases in plasma ACTH-IS and cortisol levels compared with the response to a placebo. These modulatory effects might be beneficial in stress-related diseases and suggest that this medicine has clinical pharmacological activity.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Graduate School Of Biomedical Sciences Hiroshima University
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Takeyama M
Oita Univ. Hospital
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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Ikawa Kazuro
Department Of Clinical Pharmacotherapy Division Of Clinical Pharmacotherapeutics Graduate School Of
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KATAGIRI Fumihiko
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences
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