Lack of Potentiation with Felbinac Patch on the Convulsive Toxicity of Enoxacin in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the possible potentiation of the convulsive toxicity of enoxacin (ENX) by the concomitant topical application of a felbinac (FLB) patch in rats. A felbinac patch (Seltouch^[○!R]; 0.5%, 3 cm×4 cm) was attached on the back of rats where their hair has been removed. ENX was infused from the left jugular vein at 8 h after the application of FLB patch under an unanesthetized and unstrained condition. Blood, CSF and brain samples were collected at the occurrence of convulsion, and ENX concentrations of each part were determined.As a result, no significant potentiation by FLB patch was found in the onset time of convulsion or in the ENX concentration of each part. Moreover, based on the assumption that there are no inter-species differences in ENX concentration in the brain at the occurrence of a convulsion (C_<br>), the predicted plasma ENX concentration required to elicit convulsions in humans, which was estimated from the C_<br> and K_p value of ENX in the brain of rats, was 20 times higher than the therapeutic plasma level.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
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KAWAKAMI Junichi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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OHTANI Hisakazu
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Sawada Y
Department Of Pharmaceutics Graduate School Of Pharmacertical Sciences Kyushu University
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IGA Tatsuji
International University of Health and Welfare
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Iga T
Department Of Pharmacy University Of Tokyo Hospital
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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OHTANI Hisakazu
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University
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Iga T
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Kawakami Junichi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Kawakami Junichi
Dep. Of Hospital Pharmacy Hamamatsu Univ. School Of Medicine
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NOMA Sonoe
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tok
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SAWADA Yasufumi
(Present address)Faculty of Pharmaceutical Sciences, Kyushu University
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Noma S
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Ohtani Hisakazu
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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