PREDICTION OF RENAL TUBULAR SECRETION OF TETRAETHYLAMMONIUM BROMIDE BY USE OF ENDOGENOUS N^1-METHYLNICOTINAMIDE IN THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
The renal secretion of an endogenous N^1-methylnicotinamide (NMN) and its usefulness as an index of the renal secretion clearance of tetraethylammonium bromide (TEA), a representative organic cationic drug, was examined in the rats treated with folic acid, glycerol and uranyl nitrate, respectively. There was a statistically significant correlation between the renal secretion clearance of TEA and that of NMN in the intact and acute renal failure rats (r=0.969,p<0.001). It was suggested that the renal secretion clearance of the endogenous NMN could be used as an index to assess the renal tubular function for the secretion of organic cationic drugs like TEA.
- 公益社団法人日本薬学会の論文
著者
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Shim Chang
Faculty Of Pharmaceutical Sciences University Of Tokyo : (present Address) College Of Pharmacy Seoul
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Iga T
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Sugiyama Y
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Shim Chang
Faculty Of Pharmaceutical Sciences University Of Tokyo
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