THE MECHANISM OF INTESTINAL TRANSPORT OF SULFAMETHOXAZOLE AND THE EFFECT OF CHLORPROMAZINE IN RAT EVERTED INTESTINE
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism of the intestinal transport of sulfonamides and the effect of chlorpromazine (CPZ) on it were studied using rat everted intestine in vitro. Sulfamethoxazole (SMZ) was accumulated in the serosal solution in the everted sac obeying the pH partition theory, while sulfisoxazole (SIX) was not accumulated despite the presence of the pH difference between the serosal and mucosal solutions. The reason was suggested that the microclimate pH on the mucosal surface of the intestine so decreased the amount of the unionized molecules of SIX that the transport rate of SIX was decreased to show no accumulation in the serosal solution within the sampling period. CPZ as well as metabolic inhibitors blocked the SMZ accumulation by inhibiting the growth of the pH difference. This effect was caused by the inhibition of the serosal alkalinization.
- 公益社団法人日本薬学会の論文
著者
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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IGA Tatsuji
Faculty of Pharmaceutical Sciences, University of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano M
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Nishigaki Ryuichiro
Faculty Of Pharmaceutical Sciences University Of Tokyo : (present Address) Faculty Of Pharmaceutical
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Nishigaki Ryuichiro
Faculty Of Pharmaceutical Science Toho University:college Of Pharmacy Washington State University
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HEE CHUNG
Faculty of Pharmaceutical Sciences, University of Tokyo
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Hee Chung
Faculty Of Pharmaceutical Sciences University Of Tokyo
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