A DRUG ABSORPTION MODEL OF THE INTESTINAL TRACT BASED ON THE TWO-DIMENSIONAL LAMINAR FLOW IN A CIRCULAR TUBE
スポンサーリンク
概要
- 論文の詳細を見る
A drug absorption model was developed by using the two-dimensional laminar flow in a circular tube, considering a small water absorption or secretion in the intestinal perfusion experiment. The concentration in the intestinal tract was determined by the axial component of velocity, the radial component of velocity, the membrane permeability coefficient, the reflection coefficient and so on. According to the calculated values, the concentration decreased not only from the inlet to the outlet but also from the center of the intestinal tract to the intestinal wall. The concentration at the aqueous-intestinal membrane interface was changed by the radial component of velocity, so it was suggested that the effective thickness of the aqueous diffusion layer (unstirred water layer) varies with a small water absorption or secretion.
- 公益社団法人日本薬学会の論文
著者
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IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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MIYAMOTO Yusei
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
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Miyamoto Yusei
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences University Of Tokyo:department Of Bio
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Miyamoto Yusei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Hanano Manabu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo
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ISHIKAWA MASANOBU
Department of Computer Science, Gunma University
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Ishikawa Masanobu
Department Of Chemical Engineering Faculty Of Engineering University Of Tokyo
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Miyamoto Yusei
Department Of Integrated Life Sciences The University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Department Of Pharmacy Faculty Of Pharmaceutical Sciences University Of Tokyo
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