Induction of Nitric Oxide Synthase and Subsequent Production of Nitric Oxide Not Involved in Interferon-γ-induced Hyperpermeability of Caco-2 Intestinal Epithelial Monolayers
スポンサーリンク
概要
- 論文の詳細を見る
Caco-2 cell monolayers exposed to 1000 U/ml interferon-γ(IFN-γ) for 6 days elicited inducible nitric oxide synthase (iNOS) expression and increased translayer permeability. This iNOS increase was blocked by pyrrolidinedithiocarbamate (an inhibitor of iNOS induction) but it did not suppress the hyperpermeability response. Furthermore, 2,2'-(hydroxynitrosohydrazino) bis-ethanamine (a NO donor) did not increase monolayer permeability. Therefore, IFN-γ-induced hyperpermeability is not due to its induction of iNOS activity and resulting increases in NO levels.
- 社団法人日本農芸化学会の論文
- 2001-02-23
著者
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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MIYAMOTO Yusei
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
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Miyamoto Yusei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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SATAKE Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un
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WATANABE Hirohito
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un
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Satake Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Watanabe Hirohito
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Shimizu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The University Of Tokyo
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