Absorption and Metabolism of Quercetin in Caco-2 Cells
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概要
- 論文の詳細を見る
We investigated the absorption and metabolism of quercetin, a typical flavonoid, in Caco-2 cells, which are obtained from a human colon adenocarcinoma cell line and have been used as a good model for the small intestinal epithelial cells. After incubation of Caco-2 cells with quercetin, cell homogenates were treated with sulfatase type H-5, which releases quercetin from its glucuronides and sulfates. HPLC analysis of the homogenates with an electrochemical detector revealed absorption of quercetin by the cells. The amount of quercetin in the cell homogenates treated with sulfatase type H-5 was much higher than that in the cell homogenates before treatment with the enzyme. These results indicate that quercetin was conjugated easily in Caco-2 cells and suggest that similar conjugation of flavonoids probably occurs in the intestinal epithelial cells.
- 社団法人 日本食品科学工学会の論文
- 1999-02-01
著者
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Kumazawa S
Laboratory Of Functional Food Science And Global Coe Program In The 21st Century School Of Food And
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Kumazawa S
School Of Food And Nutritional Sciences University Of Shizuoka
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Kumazawa Shigenori
静岡県立大学 食品栄養科学部
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Nakayama Tsutomu
School of Food and Nutritional Sciences, University of Shizuoka
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TERAO Junji
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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Kumazawa Shigenori
School Of Food And Nutritional Sciences University Of Shizuoka
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Kumazawa Shigenori
Mcc-group Science & Technology Research Center Mitsubishi Chemical Corporation
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HASHIMOTO Kei
Department of Bioproductive Sciences, Utsunomiya University
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IKENO Ayumi
School of Food and Nutritional Sciences, The University of Shizuoka
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Ikeno Ayumi
School Of Food And Nutritional Sciences The University Of Shizuoka
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Hashimoto Kei
Department Of Bioproductive Sciences Utsunomiya University
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Hashimoto K
Keio Univ. Yokohama Jpn
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Shimizu M
Univ. Tokyo Tokyo Jpn
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Kumazawa Shigenori
School Of Food And Nutritional Sciences And Coe Program Of 21st Century University Of Shizuoka
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Hashimoto Kimiko
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Nakayama T
Laboratory Of Functional Food Science And Global Coe Program In The 21st Century School Of Food And
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Nakayama Tsutomu
School Of Food And Nutritional Sciences University Of Shizuoka
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Shimizu M
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Terao Junji
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Hashimoto Kensuke
Faculty Of Engineering Fukuyama University
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Shimizu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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HASHIMOTO Kei
Department of Applied Biological Chemistry, Utsunomiya University
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