Evaluation of Intestinal Dioxin Permeability Using Human Caco-2 Cell Monolayers

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概要

• 論文の詳細を見る

• A system to evaluate the intestinal permeability for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was constructed with human intestinal Caco-2 cell monolayers. TCDD was added to the apical side of the cell monolayers and the basal TCDD concentration was estimated by using a HepG2 cell having a luciferase vector with a xenobiotic-responsive element in the promoter region. Addition of such food substances as chlorophyll to the apical side of the Caco-2 cell monolayers markedly decreased the apical-to-basal transport of TCDD. This system would be useful for use in searching for the materials having an inhibitory activity to intestinal TCDD absorption.

• 社団法人　日本食品科学工学会の論文
• 2003-11-01

著者

• SATSU Hideo

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• SHIMIZU Makoto

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• SATO Ryuichiro

  Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The Un

• Satsu Hideo

  Department Of Applied Biological Chemistry Division Of Agricultural And Life Sciences The University

• Sato R

  Univ. Tokyo Tokyo Jpn

• Shimizu M

  Univ. Tokyo Tokyo Jpn

• Ashida H

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Ashida Hitoshi

  Department Of Agricultural Chemistry Kobe University

• Ashida Hitoshi

  Graduate School Of Science & Technology Division Of Life Science Kobe University

• Tukey Robert

  Department Of Chemistry Biochemistry & Pharmacology University Of California

• WATANABE Hirohito

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un

• Watanabe Hirohito

  Department Of Life Science Meiji University

• Watanabe Hirohito

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ

• Shimizu Makoto

  Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• NATSUME Yayoi

  Department of Applied Biological Chemistry, The University of Tokyo

• HATSUGAI Yasuo

  Department of Applied Biological Chemistry, The University of Tokyo

• Ashida Hitoshi

  Department Of Life Science Graduate School Of Science And Technology Kobe University

• Satsu Hideo

  Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of

• Satsu H

  Univ. Tokyo Tokyo Jpn

• Sato Ryuichiro

  Dep. Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences Univ. Of Tokyo

• Ashida Hitoshi

  Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.

• Hatsugai Yasuo

  Department Of Applied Biological Chemistry The University Of Tokyo

• Sato R

  Department Of Applied Biological Chemistry The University Of Tokyo

• Sato Ryuichiro

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Shimizu M

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Ashida Hitoshi

  Graduate School Of Agricultural Science Kobe University

• Natsume Yayoi

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Sato Ryuichiro

  Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un

• Shimizu Makoto

  Department Of Applied Biological Chemistry The University Of Tokyo

• Shimizu Makoto

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Shimizu Makoto

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• SATO Ryuichiro

  Department of Agricultural Chemistry, The University of Tokyo

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