Quercetin Enhances VDR Activity, Leading to Stimulation of Its Target Gene Expression in Caco-2 Cells
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概要
- 論文の詳細を見る
Vitamin D receptor (VDR) is a nuclear receptor that regulates the expression of genes involved in calcium homeostasis. Activation of VDR is thought to be a promising drug target for osteoporosis. Using a VDR-driven luciferase expression assay for screening a naturally occurring food component, we identified quercetin as a VDR activator. Quercetin also activated the GAL4 DNA-binding domain fused to the VDR ligand-binding domain. Moreover, it was confirmed that quercetin increases the mRNA level of TRPV6, which is a VDR target gene, in Caco-2 cells. These results indicate that quercetin enhances VDR activity through the alteration of cofactor recruitment, thereby stimulating its target genes while providing a new function for quercetin as the VDR activator.
- 財団法人 学会誌刊行センターの論文
- 2010-10-01
著者
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INOUE Jun
Department of Internal Medicine, Tohoku University Hospital
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SATO Ryuichiro
Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The Un
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Sato Ryuichiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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CHOI Jung-Min
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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YOSHIDOMI Takehiro
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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YASHIRO Takuya
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Choi Jung-min
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Yashiro Takuya
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Inoue Jun
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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Yoshidomi Takehiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Inoue Jun
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Inoue Jun
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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SATO Ryuichiro
Department of Agricultural Chemistry, The University of Tokyo
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