Structural Effects of Phenolic Acids on the Transepithelial Transport of Fluorescein in Caco-2 Cell Monolayers(Food & Nutrition Science)
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概要
- 論文の詳細を見る
The structural specificity of the monocarboxylic acid transporter (MCT) for the transport of phenolic acids was investigated by measuring the inhibitory effect on the fluorescein transport in Caco-2 cell monolayers. Although most of the monohydroxylated derivatives had an inhibitory effect, the di- and tri-hydroxylated ones did not. The methoxylated derivatives were more inhibitory than the hydroxylated ones in all the meta-substituted derivatives, suggesting that meta-hydroxylation of the substrate would decrease the affinity for MCT.
- 社団法人日本農芸化学会の論文
- 2003-09-23
著者
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Kubo K
Mitsubishi Electric Corp. Kamakura‐shi Jpn
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Kubo Kazuo
Pharmaceutical Research Laboratories Pharmaceutical Division Kirin Brewery Co. Ltd.
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Konishi Yutaka
Applied Bioresearch Center Research & Development Department Kirin Brewery Co. Ltd.
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Konishi Yutaka
Applied Bioresearch Center Research & Development Department
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Konishi Yutaka
Applied Bioresearch Center Kirin Brewery Co. Ltd.
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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