Human Milk Bile-salt-stimulated Lipase Is Extremely Reactive with the Monoclonal Antibody 1CF11 which Recognizes a Human-specific Carbohydrate Antigen

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概要

• 論文の詳細を見る

• 1CF11 (Kanamaru, Y. et al.; Biochem.Biophys.Res.Commun., 249,618-623,1998) is a monoclonal antibody obtained after being raised in a mouse by injection of human milk MUC1 mucin as the antigen. Its reactivity was found to be unique in that it only reacts with a carbohydrate epitope shared by glycoproteins in human secretions, while its chemical nature is still unknown. Since a glycoprotein of Mr 135,000 (135K) in human milk was found to react extremely strongly with this antibody, we intended in this study to isolate the glycoprotein by a combination of various chromato-graphic techniques and identify it. It is a human milk bile-salt-stimulated lipase. By comparison of its immunoreactivity and glycan structures so far reported with those of lactoferrin from human milk, it is suggested that the epitope recognized by mAb 1CF11 could be a human-specific novel glycan.

• 社団法人日本農芸化学会の論文
• 2001-04-23

著者

• Nagaoka Satoshi

  Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University

• KANAMARU Yoshihiro

  Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University

• SHIMIZU Makoto

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• Shimizu M

  Univ. Tokyo Tokyo Jpn

• Nagaoka S

  Gifu Univ. Gifu Jpn

• Nagaoka Satoshi

  Institute Of Physics University Of Tokyo

• SHIMOYAMADA Makoto

  Department of Bioprocessing, Faculty of Agriculture, Gifu University

• 金丸 美敬

  Dep. Of Applied Life Sci. Gifu Univ.

• Kanamaru Yoshihiro

  Department Of Food Science Faculty Of Agriculture Gifu University

• Kanamaru Yoshihiro

  Department Of Food Science Faculty Of Applied Biological Science Gifu University

• YANG Shan-Ming

  Department of Food Science, Faculty of Agriculture, Gifu University

• SACHDEV Goverdhan

  College of Pharmacy, University of Oklahoma Health Sciences Center

• Yang Shan-ming

  Department Of Food Science Faculty Of Agriculture Gifu University

• ASANO Fumiyuki

  Department of Food Science, Faculty of Agriculture, Gifu University

• Shimizu M

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Shimoyamada Makoto

  Department Of Food Science Faculty Of Agriculture Gifu University

• Kanamaru Yoshihiro

  Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University

• Kanamaru Yoshihiro

  Faculty Of Applied Biological Sciences Gifu University

• Asano Fumiyuki

  Department Of Food Science Faculty Of Agriculture Gifu University

• Nagaoka Satoshi

  Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University

• Shimizu Makoto

  Department Of Applied Biological Chemistry The University Of Tokyo

• Shimizu Makoto

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Shimizu Makoto

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• Sachdev Goverdhan

  College Of Pharmacy University Of Oklahoma Health Sciences Center

• Nagaoka Satoshi

  Department of Food Science, Faculty of Agriculture, Gifu University

• NAGAOKA Satoshi

  Institute of Physics, University of Tokyo

• NAGAOKA Satoshi

  Department of Agricultural Chemistry, Faculty of Horticulture, Chiba University

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