Effects of Dipeptides Having a C-Terminal Lysine on the Cholesterol 7α-Hydroxylase mRNA Level in HepG2 Cells
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概要
- 論文の詳細を見る
Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7α-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.
- 社団法人 日本農芸化学会の論文
著者
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ISHIKAWA Kumiko
Department of Pediatric Hematology-Oncology, Institute of Medical Science, University of Tokyo
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Nagaoka Satoshi
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
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KANAMARU Yoshihiro
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
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MORIKAWA Kensei
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
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HORI Goro
Kyowa Hakko Kogyo Co., Ltd.
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