A Cattle Heart Protein Hydrolysate Ameliorates Hypercholesterolemia Accompanied by Suppression of the Cholesterol Absorption in Rats and Caco-2 Cells

スポンサーリンク

概要

• 論文の詳細を見る

• The mechanism for the hypocholesterolemic action of a cattle heart protein hydrolysate (HPH) is clarified. The micellar solubility of cholesterol in vitro was significantly lower in the presence of HPH than in the presence of casein. The suppression of cholesterol uptake by Caco-2 cells was significantly higher in the cholesterol micelles containing HPH than in the cholesterol micelles containing casein. The serum cholesterol concentrations and atherogenic index were significantly lower in the rats fed with HPH than in those fed with casein. The cholesterol absorption measured by [3H]-cholesterol was significantly lower by HPH feeding than by casein feeding in rats in vivo accompanying the changes in fecal steroid excretion. Thus, the hypocholesterolemic action of HPH involved the inhibition of jejunal cholesterol absorption. The cattle heart protein hydrolysate ultra-filtrate (HPHU, MW < ca. 1,000 Da peptide fraction) derived from HPH imparted stronger hypocholesterolemic activity than HPH in rats.

• 社団法人 日本農芸化学会の論文
• 2009-03-23

著者

• Nagaoka Satoshi

  Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University

• NAKADE Koji

  Central Research Institute, Itoham Foods Inc.

• NUMATA Masahiro

  Central Research Institute, Itoham Foods Inc.

• Muguruma Michio

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Muguruma Michio

  Faculty Of Agriculture Miyazaki University

• Muguruma Michio

  Laboratory Of Food Science And Nutrition Department Of Biochemistry And Applied Biosciences Faculty

• Muguruma Michio

  Department Of Animal Science Faculty Of Agriculture Kyushu University

• Muguruma M

  Kyushu Univ. Fukuoka

• Oka Takao

  Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University

• Kaneko Hideki

  Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University

• Nakade Koji

  Central Research Institute Itoham Foods Inc.

• Nagaoka Satoshi

  Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University

• AHHMED Abdulatef

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Ahhmed Abdulatef

  Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki

• Numata Masahiro

  Central Research Institute Itoham Foods Inc.

• Nakade Koji

  Central Research Institute Itoham Food Inc.

• Numata Masahiro

  Central Research Institute Itoham Food Inc.

• NAGAOKA Satoshi

  Department of Agricultural Chemistry, Faculty of Horticulture, Chiba University

関連論文

• Soystatin (VAWWMY), a Novel Bile Acid-Binding Peptide, Decreased Micellar Solubility and Inhibited Cholesterol Absorption in Rats
• Identification of an antihypertensive peptide derived from chicken bone extract
• Quantitative Expression Analysis of Inulinase Gene Cluster of Penicillium sp. Strain TN-88(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
• Acidophilic Xylanase from Aureobasidium pullulans : Efficient Expression and Secretion in Pichia pastoris and Mutational Analysis(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• Molecular Cloning and Characterization of an Exoinulinase Gene from Aspergillus niger Strain 12 and Its Expression in Pichia pastoris
• Reaction of 2-(Alkylthiomethyl)phenyllithium with Copper(I) Halides and Structure and Properties of One of the Products -Copper(I) Complexes of 2,2'-Bis(alkylthiomethyl)biphenyl^
• Unique Occurrence of the 1CF11 Carbohydrate Epitope in Primate Saliva
• Involvement of SDS-Stable Higher M_r Forms of Bovine Normal Milk α-Lactalbumin in Inducing Intestinal IEC-6 Cell Death
• IEC-6 Intestinal Cell Death Induced by Bovine Milk α-Lactalbumin
• Effects of humidity-stabilizing sheets on the quality of bigeye tuna meat (Thunnus obesus) during refrigerated storage
• Human Milk Bile-salt-stimulated Lipase Is Extremely Reactive with the Monoclonal Antibody 1CF11 which Recognizes a Human-specific Carbohydrate Antigen
• Reactivity of the High-M_r Mucin-like Glycoproteins in Human Milk with Monoclonal Antibodies HMFG-1 and HMFG-2
• High Molecular Weight Mucin-like Glycoprotein in Bovine Milk
• Comparative Studies on the Serum Cholesterol Lowering Action of Whey Protein and Soybean Protein in Rats
• Effects of Whey Protein and Casein on the Plasma and Liver Lipids in Rats(Food & Nutrition)
• Serum Cholesterol Reduction and Cholesterol Absorption Inhibition in CaCo-2 Cells by a Soyprotein Peptic Hydrolyzate
• Optical Measurements during Gelation Process of Muscle Protein under High Pressure
• Isolation of an Antioxidant from PenicilIium roquefortii IFO 5956
• Evaluation of beef tallow as a natural source of conjugated linoleic acid
• Effects of Dipeptides Having a C-Terminal Lysine on the Cholesterol 7α-Hydroxylase mRNA Level in HepG2 Cells
• Purification and characterization of an angiotensin I-converting enzyme inhibitory peptide derived from porcine troponin C
• The Bovine Lactophorin C-Terminal Fragment and PAS6/7 Were Both Potent in the Inhibition of Human Rotavirus Replication in Cultured Epithelial Cells and the Prevention of Experimental Gastroenteritis
• Studies on the 9 cis, 11 trans Conjugated Linoleic Acid Contents of Meat and Dairy Products
• Soystatin (VAWWMY), a Novel Bile Acid-Binding Peptide, Decreased Micellar Solubility and Inhibited Cholesterol Absorption in Rats
• A Cattle Heart Protein Hydrolysate Ameliorates Hypercholesterolemia Accompanied by Suppression of the Cholesterol Absorption in Rats and Caco-2 Cells
• Soy Protein Hydrolyzate with Bound Phospholipids Reduces Serum Cholesterol Levels in Hypercholesterolemic Adult Male Volunteers
• Effects of Dipeptides Having a C-Terminal Lysine on the Cholesterol 7α-Hydroxylase mRNA Level in HepG2 Cells
• Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat
• Observation of Transmitted Light Spectra during Gelation Process of Actomyosin
• Organization of the Functional Domains in Membrane Cytoskeletal Protein Talin^1
• Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis(METHODS)
• Novel Method of Measuring Surface Torsional Anchoring Strength of Nematic Liquid Crystals
• The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products
• Simple method for isolation of glyceraldehyde 3-phosphate dehydrogenase and the improvement of myofibril gel properties
• A case of Behcet's disease with widespread perforating enteric ulcers preceded by a long history of peripheral gangrene
• Changes in water-holding capacity and textural properties of chicken gizzard stored at 4℃
• Application of Probiotics from Mongolian Dairy Products to Fermented Dairy Products and Its Effects on Human Defecation
• Effects of Oral Administration of Probiotics from Mongolian Dairy Products on the Th1 Immune Response in Mice
• Molecular Interaction Studies Evaluating the Gelation of Myosin B with Glyceraldehyde 3-phosphate Dehydrogenase after Succinylation
• Methyl Viologen-linked Nitrite Reductase from Bean Roots
• Molecular Interaction Studies Evaluating the Gelation of Myosin B with Glyceraldehyde 3-phosphate Dehydrogenase after Succinylation

もっと見る 閉じる

スポンサーリンク