Effects of Dipeptides Having a C-Terminal Lysine on the Cholesterol 7α-Hydroxylase mRNA Level in HepG2 Cells
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概要
- 論文の詳細を見る
Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7α-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.
- 社団法人 日本農芸化学会の論文
- 2007-03-23
著者
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Nagaoka Satoshi
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
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Nagaoka Satoshi
Department Of Food Science Faculty Of Applied Biological Science Gifu University
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金丸 美敬
Dep. Of Applied Life Sci. Gifu Univ.
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Kanamaru Yoshihiro
Department Of Food Science Faculty Of Agriculture Gifu University
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Kanamaru Yoshihiro
Department Of Food Science Faculty Of Applied Biological Science Gifu University
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MORIKAWA Kensei
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
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HORI Goro
Kyowa Hakko Kogyo Co., Ltd.
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Kanamaru Yoshihiro
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
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Kanamaru Yoshihiro
Faculty Of Applied Biological Sciences Gifu University
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Ishikawa Kumiko
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
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Nagaoka Satoshi
Fac. Of Applied Biological Sciences Gifu Univ.
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Nagaoka Satoshi
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
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Hori Goro
Kyowa Hakko Kogyo Co. Ltd.
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Morikawa Kensei
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
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NAGAOKA Satoshi
Department of Agricultural Chemistry, Faculty of Horticulture, Chiba University
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