Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells
スポンサーリンク
概要
- 論文の詳細を見る
This study demonstrates the effect of soybean components on the tumor necrosis factor-α (TNF-α)-induced production of interleukin-8 (IL-8), one of the major inflammatory chemokines, in intestinal epithelial-like Caco-2 cells. Among the soybean components, an isoflavone fraction (IFF) suppressed the TNF-α-induced IL-8 secretion by Caco-2 cells in a dose-dependent manner, whereas a soyasaponin fraction and soypeptide fraction had no significant effect on TNF-α-induced IL-8 secretion. The IL-8 secretion induced by hydrogen peroxide and by IL-1β was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-α-induced regulation of IL-8. The increased expression of IL-8 mRNA by TNF-α was almost completely suppressed by IFF. Furthermore, the transcriptional activity of the human IL-8 promoter was increased by the TNF-α treatment, and IFF significantly suppressed the IL-8 promoter activity. These results indicate that IFF suppressed TNF-α-induced IL-8 production at the transcriptional level in human intestinal Caco-2 cells, suggesting IFF of soybean as a promising food component for preventing intestinal inflammation such as inflammatory bowel disease.
- 2009-10-01
著者
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SATSU Hideo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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HYUN Ja
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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SHIN Hee
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Hyun Ja
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shin Hee
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Satsu Hideo
Department Of Applied Biological Chemistry Division Of Agricultural And Life Sciences The University
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Satsu Hideo
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Satsu H
Univ. Tokyo Tokyo Jpn
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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