In vivo Insulin Sensitivity and Insulin Binding to Erythrocytes in Children : Insulin Resistance in Obese Children
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概要
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This aim of this study was to determine whether RBC insulin receptor assay represents a clinically useful way of assessing insulin sensitivity in obes children. Steady state plasma glucose (SSPG) was established by a constant infusion of glucose (6 mg/kg/min), insulin (0.8 mU/kg/min) and somatostatin (125μg/m<SUP>2</SUP>/h), following the loading dose of somatostatin (125μg/m<SUP>2</SUP>). Insulin binding to RBCs was measured by a modified method of Gambhir and was compared with SSPG.<BR>Of 21 children with various relative body weight, 8 hyperinsulinemic obese children had a decreased insulin binding to RBCs due to decreased receptor concentrations.<BR>The insulin binding was inversely correlated with the fasting serum insulin level and with the insulin area under the O-GTT insulin response curve. In 11 children with various relative body weight, a highly significant inverse relationship was found between SSPG and insulin binding. SSPG was also correlated with the fasting serum insulin level.<BR>It was concluded that RBC insulin receptor may quantitatively reflect insulin resistance in obese children, and may be a useful tool for clinical evaluation of tissue insulin sensitivity in children.
- 社団法人 日本内分泌学会の論文
著者
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Amemiya Shin
Department Of Pediatrics Faculty Of Medicine University Of Yamanashi
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KATO Kiyohiko
Department of Materials Science, Faculty of Engineering, Kitami Institute of Technology
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Asayama Kohtaro
Department Of Pediatrics School Of Medicine University Of Occupational And Environmental Health
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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AMEMIYA SHIN
Department of Pediatrics, School of Medicine, Keio University
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KATO KIYOHIKO
Department of Pediatrics, Yamanashi Medical School
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ASAYAMA KOHTARO
Department of Pediatrics, School of Medicine, Keio University
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SHIMIZU MAKOTO
Department of Pediatrics, School of Medicine, Keio University
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