Identification of a Taurine Transport Inhibitory Substance in Sesame Seeds
スポンサーリンク
概要
- 論文の詳細を見る
An ethanol extract from sesame seeds inhibited the taurine uptake in human intestinal epithelial Caro-2 cells. The uptake of such α-amino acids as leucine and glutamic acid was not inhibited by the extract, indicating that this inhibition is specific to the taurine uptake. The unknown inhibitor in the sesame extract was purified by reversed-phase HPLC by monitoring the inhibitory effect on taurine uptake. The isolated substance was identified as lysophosphatidylcholine, linoleoyl (Lyso-PC), by NMR and MS analysis. Lyso-PC inhibited the taurine uptake in a dose-dependent manner with an IC_<50> value of approximately 200μM. Although Lyso-PC is known to be a surface active and cell lytic compound, neither damage nor loss of integrity of the Caco-2 cell monolayer was apparent after treating with 200μM Lyso-PC. Inhibition was observed by incubating cells with Lyso-PC for only 1 min prior to the uptake experiments. These results suggest the direct effect of Lyso-PC on the cell membrane to be the main mechanism for this inhibition. Lyso-PC may play a role in the regulation of certain intestinal transporters.
- 社団法人日本農芸化学会の論文
- 2000-06-23
著者
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FURIHATA Kazuo
Department of Applied Biological Chemistry, The University of Tokyo
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SATSU Hideo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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MIYAMOTO Yusei
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
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Satsu Hideo
Department Of Applied Biological Chemistry Division Of Agricultural And Life Sciences The University
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Shimizu M
Univ. Tokyo Tokyo Jpn
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Miyamoto Yusei
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences University Of Tokyo:department Of Bio
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Miyamoto Yusei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Furihata Kazuo
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Furihata Kazuo
Department Of Applied Biological Chemistry The University Of Tokyo
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Satsu Hideo
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Satsu H
Univ. Tokyo Tokyo Jpn
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Miyamoto Yusei
Department Of Integrated Life Sciences The University Of Tokyo
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ISHIZUKA Koji
Department of Applied Biological Chemistry, The University of Tokyo
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Ishizuka Koji
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu M
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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KANAYAMA Atsuhiro
Department of Applied Biological Chemistry, The University of Tokyo
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Kanayama Atsuhiro
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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