Inhibition of P-Glycoprotein Enhances the Suppressive Effect of Kaempferol on Transformation of the Aryl Hydrocarbon Receptor
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概要
- 論文の詳細を見る
Dioxins enter the body mainly through the diet, bind to the aryl hydrocarbon receptor (AhR), and cause various toxicological effects. In this study, we found that oral administration of kaempferol or ginkgo biloba extract (EGb) containing 24% flavonol at 100 mg/kg body weight suppressed AhR transformation induced by 3-methylcholanthrene at 10 mg/kg body weight in the liver of mice. The suppressive effect of kaempferol was enhanced by verapamil, an inhibitor of P-glycoprotein (P-gp), in ex vivo experiments using a hepatic cytosolic fraction and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Enhancement of the suppressive effect by verapamil was also observed in mouse hepatoma Hepa-1c1c7 cells, accompanied by an increase in the uptake of kaempferol into the cells. In conclusion, inhibition of P-gp enhanced the suppressive effect of kaempferol on AhR transformation through an increase in the intracellular kaempferol concentration.
- 社団法人 日本農芸化学会の論文
- 2009-07-23
著者
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Mukai Rie
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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ASHIDA Hitoshi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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SATSU Hideo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Satsu Hideo
Department Of Applied Biological Chemistry Division Of Agricultural And Life Sciences The University
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Shimizu M
Univ. Tokyo Tokyo Jpn
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Ashida H
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Ashida Hitoshi
Department Of Agricultural Chemistry Kobe University
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Ashida Hitoshi
Graduate School Of Science & Technology Division Of Life Science Kobe University
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Ashida Hitoshi
Department Of Life Science Graduate School Of Science And Technology Kobe University
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Satsu Hideo
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Satsu H
Univ. Tokyo Tokyo Jpn
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Ashida Hitoshi
Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.
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Shimizu M
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Mukai Rie
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Mukai Rie
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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