Tryptophan Pyrolysis Products, Trp-P-1 and Try-P-2 Induce Apoptosis in Primary Cultured Rat Hepatocytes

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概要

• 論文の詳細を見る

• The cytotoxicity of heterocyclic amines, dietary carcinogens derived from cooked foods, to primary cultured rat hepatocytes was studied. A tryptophan pyrolysis product, 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Try-P-1) was the most cytotoxic of 11 compounds tested. Trp-P-1 was found to induce apoptosis as measured by morphological changes in nuclear chromatin and internucleosomal DNA fragmentation. 3-Amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) showed a moderate apoptotic effect, and other compounds had a similar but weaker effect.

• 社団法人日本農芸化学会の論文
• 1998-11-23

著者

• HASHIMOTO Takashi

  Department of Biochemistry, Shinshu University School of Medicine

• ASHIDA Hitoshi

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

• Kanazawa K

  Laboratory Of Food And Nutritional Chemistry Graduate School Of Agriculture Kobe University

• Kanazawa Kazuki

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Kanazawa Kazuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University

• DANNO Gen-ichi

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• SHIOTANI Bunsyo

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• ADACHI Hideya

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• Adachi Hideya

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Kanazawa K

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Kanazawa Kazuki

  Department Of Biosystems Science Graduate School Of Agricultural Science Kobe University

• Ashida H

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Ashida Hitoshi

  Department Of Utilization Of Biological Resources Kobe University

• Ashida Hitoshi

  Department Of Agricultural Chemistry Kobe University

• Ashida Hitoshi

  Graduate School Of Science & Technology Division Of Life Science Kobe University

• Hashimoto T

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Ashida Hitoshi

  Department Of Life Science Graduate School Of Science And Technology Kobe University

• Ashida Hitoshi

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University:research Center

• Ashida Hitoshi

  Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.

• Danno G

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Danno Gen-ichi

  Department Of Agricultural Chemistry Kobe University

• Hashimoto T

  Graduate School Of Agricultural Sci. Kobe Univ.

• Shiotani Bunsyo

  Division Of Life Science Graduate School Of Science And Technology Kobe University

• Hashimoto Takashi

  Department Of Biochemistry Shinshu University School Of Medicine

• Hashimoto Takashi

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

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