STEREOSPECIFIC FORMATION OF (24R, 25R)-3α, 7α, 12α, 24-TETRAHYDROXY-5β-CHOLESTAN-26-OIC ACID CATALYZED WITH A PEROXISOMAL BIFUNCTIONAL D-3-HYDROXYACYL-CoA DEHYDRATASE/D-3-HYDROXYACYL-CoA DEHYDROGENASE

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概要

• 論文の詳細を見る

• The absolute configuration of 3α, 7α, 12α, 24-tetrahydroxy-5β-cholestan-26-oic acid CoA ester (V-CoA) produced by the incubation of (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid CoA ester (24E-THC-CoA) with D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase (D-bifunctional protein) was investigated. When 24E-THC-CoA was incubated with D-bifunctional protein the formation of only one isomer (24R, 25R-isomer) of four possible stereoisomers of V-CoA was observed, which suggested the cis-addition of water to a side chain double bond of 24E-THC-CoA. The dehydration reaction of V-CoA catalyzed by D-bifunctional protein was also observed when (24R, 25R)-V-CoA was used as a substrate. The other three isomers (24R, 25S-, 24S, 25R- and 24S, 25S-isomers) were not dehydrated with D-bifunctional protein. These results showed that D-bifunctional protein catalyzes stereospecifically the hydration and dehydration step in bile acid biosynthesis.

• 社団法人日本薬学会の論文
• 1997-03-15

著者

• 黒澤 隆夫

  北海道大学医学部附属病院 検査部

• SATO Masahiro

  Faculty of Industrial Science and Technology, Tokyo University of Science

• KUROSAWA Takao

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• Kurosawa T

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Kurosawa Takao

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• HASHIMOTO Takashi

  Department of Biochemistry, Shinshu University School of Medicine

• 吉村 昭毅

  北海道医療大学薬学部

• Kurosawa Takao

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Hiramoto Toshirou

  Device Development Center Hitachi Ltd.

• YOSHIMURA Teruki

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• TOHMA Masahiko

  Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido

• JIANG Ling

  Department of Biochemistry, Shinshu University School of Medicine

• Yoshimura Teruki

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• 佐藤 真友美

  Univ. Shizuoka Shizuoka Jpn

• Jiang Ling

  Department Of Biochemistry Shinshu University School Of Medicine

• Hashimoto T

  Graduate School Of Biological Sciences Nara Institute Of Science And Technology

• Sato Masahiro

  Kakuda Research Center National Aerospace Laboratory

• Tohma Masahiko

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Tohma M

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Yoshimura T

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Hashimoto Takashi

  Department Of Biochemistry Shinshu University School Of Medicine

• Sato Masahiro

  Faculty Of Education And Human Studies Akita University

• Hashimoto Takashi

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

• TOHMA MASAHIKO

  Faculty of Pharmaceutical Science, Higashi-Nippon-Gakuen University

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