Synthesis of C-2 Catecholic Equilin and Equilenin Derivatives for Use in Metabolic Studies
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概要
- 論文の詳細を見る
In order to clarify the metabolic fate of equine estrogens, 2-hydroxyequilin, 2-hydroxy-equilenin and their isomeric monomethyl ethers were synthesized as authentic specimens. Vanillin and isovanillin were employed as starting materials leading to the desired β-ketosulfoxides (2a, b). Condensatin of the α, β-unsaturated ketones (4a, b) obtained by thermal elimination of 3a and 3b with 2-methylcyclopentane-1,3-dione provided the triketones (5a, b), which were cyclized to the estrapentens (6a, b). Several oxido-reduction reactions were then performed to give the title compounds (8,13).
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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藤間 貞彦
Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University
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黒澤 隆夫
Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University
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黒澤 隆夫
北海道大学医学部附属病院 検査部
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藤間 貞彦
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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Kurosawa T
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Kurosawa Takao
Health Sci. Univ. Hokkaido Hokkaido Jpn
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池川 繁男
近畿大学薬学部
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池川 繁男
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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Ikegawa S
Health Sci. Univ. Hokkaido Hokkaido Jpn
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黒澤 隆夫
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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