Optical Rotatory Dispersions of β-Hydroxylated 5β-Spirostanones
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概要
- 論文の詳細を見る
The β-axial hydroxylated 5β-spirostan-1- and 3-ones were prepared from the steroidal sapogenins in Convallaria and diosgenin, and the optical rotatory dispersion curves of these ketones were measured in methanol or dioxane. The 5-hydroxy-25 (R), 5β-spirostan-3-one (XIII) showed a weak positive amplitude (a : +16.0) in contrast to the negative one of the parent 3-ketone (I, a : -16.6). The hydroxyl groups substituted on the symmetrical β-axial positions to the carbonyl groups led to marked changes in the amplitude of Cotton effect in the 5β-spirostanones, and opposed to the prediction from the octant rule.
- 公益社団法人日本薬学会の論文
- 1972-10-25
著者
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藤間 貞彦
Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University
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藤間 貞彦
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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山崎 克彦
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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藤野 明治
Faculty of Pharmaceutical Sciences, Hokkaido University
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藤野 明治
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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