^1H- and ^<13>C-Nuclear Magnetic Resonance Spectra of Testosterone and 17β-Hydroxyandrosta-4,6-dien-3-one in Sulfuric Acid
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概要
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The behavior of testosterone (I) and 17β-hydroxyandrosta-4,6-dien-3-one (VII) in sulfuric acid was investigated by absorption and ^1H- and ^<13>C-nuclear magnetic resonance (NMR) spectroscopic studies. I and VII were demonstrated to give initially the diprotonated species, II and VIII, respectively and then the dication (x-300,III), which is the intermediate in the color and fluorescence reaction of I with strong acids. The conjugate base of x-300,17-methyl-18-norandrosta-4,8 (14), 13 (17)-trien-3-one (IV), was isolated from the reaction mixture of VII with 97% sulfuric acid. Thus, the chemical structure of x-300 was fully elucidated and the reaction mechanism previously proposed was confirmed.
- 社団法人日本薬学会の論文
- 1982-09-25
著者
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三浦 敏明
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty of Pharmaceutical Sciences, Hokkaido University
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安達 健一
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty Of Pharmaceutical Sciences Hokkaido University
-
安達 健一
Faculty Of Pharmaceutical Sciences Hokkaido University
-
木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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