不飽和ケトステロイドの硫酸中の^<13>C-核磁気共鳴スペクトル
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概要
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エノン,ジエノン,トリエノン及びテトラエノン構造を有する一連の不飽和ケトステロイド(IIa,IIIa, IVa, Va)の重クロロホルム中及び硫酸中の^<13>C-核磁気共鳴(NMR)スペクトルを測定した.これらの不飽和ケトステロイドは,適当な濃度の硫酸中でそれぞれ,ヒドロキシアルケニル陽イオン(IIb),ヒドロキシアルカジエニル陽イオソ(IIIb),ヒドロキシアルカトリエニル陽イオン(IVb)及びヒドロキシアルカテトラエニル陽イオン(Vb)に変化した.陽イオンのsp^2炭素シグナルの帰属は,対応する共役塩基のNMRデータとの比較並びに陽イオンのNMRデータの相互比較により,合理的に行うことができた.IVb及びVbはテストステロンの硫酸による反応で生成する発色・発蛍光休であり,先にそれらの構造を^1H-NMR法によって証明したが,今回得られた^<13>C-NMRデータにより,それらの構造を確証することができた.
- 1984-10-05
著者
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木村 道也
北海道大学薬学部
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
北海道大学薬学部
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三浦 敏明^
北海道大学薬学部
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高木 英利
Faculty Of Pharmaceutical Sciences Hokkaido University
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三浦 敏明^[○!R]
北海道大学薬学部
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木村 道也
北海道大学医学部薬学科
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