D-Homoannulation in the Color and Fluorescence Reaction of 17α-Hydroxyprogesterone with Sulfuric Acid
スポンサーリンク
概要
- 論文の詳細を見る
Dissolution of 17α-hydroxyprogesterone (1) in 80% sulfuric acid gave two D-homosteroids through C (13)-C (17) bond migration, 17aβ-hydroxy-17aα-methyl-D-homoandrost-4-ene-3,17-dione (2) and 17a-methylene-D-homoandrost-4-ene-3,17-dione (3), in 53 and 9% yields, respectively. The latter product was also obtained in 73% yield from the reaction of 1 with 90% sulfuric acid. Proton nuclear magnetic resonance (^1H-NMR) studies of the acid solutions revealed that the D-homoannulation of 1 to 2 occurs rapidly even in 80 or 90% sulfuric acid, and that 2 is dehydrated rapidly to 3 in 90% sulfuric acid. The D-homoannulation was demonstrated to be an initial step in the color and fluorescence reaction of 1 with sulfuric acid.
- 社団法人日本薬学会の論文
- 1985-08-25
著者
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早川 達
Faculty Of Pharmaceutical Sciences Hokkaido University
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三浦 敏明
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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