Autoxidation of Nor- and Tauro-deoxycholic Acids in the Presence of Ferrous Ions
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概要
- 論文の詳細を見る
Reactions with the simple aerobic hydroxylating system at moderate temperature were studied on the aqueous solutions of two varieties of bile acid. Ferrous sulfate was added to a buffered solution (pH 6.5-6.7) of nordeoxycholic acid which was bubbled with molecular oxygen, as reported. The structures of the methylated products were elucidated as methyl 24-nor-3α, 12α, 15α-trihydroxy-5β-cholan-23-oate and methyl 24-nor-3α, 12α-dihydroxy-15-oxo-5β, 14β-cholan-23-oate. Oxygen function was introduced also stereospecifically at C_<15> and in an α-configuration when taurodeoxycholic acid was treated with the same hydroxylating system.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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山崎 克彦
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
Faculty of Pharmaceutical Sciences, Hokkaido University
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藤野 明治
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
北海道大学 薬
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藤野 明治
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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