Chromogenic Reactions of Steroids with Strong Acids. XI. Mechanism of Chromogenic Reaction of Testosterone with Sulfuric Acid
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概要
- 論文の詳細を見る
Mechanism was investigated for the chromogenic reaction of testosterone (I) with sulfuric acid. Dication (II in Chart 1) produced at the primary stage of the reaction was transformed into the chromophoric χ-484 (XIIa in Chart 4) via its conjugate base (VIII in Chart 4) by acid-base catalyzed isomerization. The conjugate base of the χ-484 (XIIb), 17,17-dimethyl-18-norandrosta-4,6,8 (14)-trien-3-one (XIb), was isolated in 40% yield in the reaction of the epoxide (V in Chart 2) with sulfuric acid. Sulfuric acid solution of the trienone (XIa, b) showed a maximum absorption at 484 nm (ε=42000). The pK_a value of XIIa was also determined.
- 社団法人日本薬学会の論文
- 1979-03-25
著者
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三浦 敏明
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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