Autoxidation of Taurocholanic Acid in Aqueous Solution of Ferrous Ions
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概要
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Taking into account the possible effect of the polar group located in the side chain, the autoxidation of taurocholanic acid in neutralized aqueous solution was carried out with the ferrous ions-molecular oxygen system at 70° for 4 hours. The taurocholanates of the reaction mixture were collected on a column packed with XAD-2 resin, then saponified to the free bile acids, and finally esterified for convenience of purification to obtain the methylated products. Attack of the hypothetical ferrous dioxygen complex seemed to occur in the ring D as expected, since the structure of the product B was assumed to be methyl 15α-hydroxy-5β-cholan-24-oate. Thin-layer as well as gas-liquid chromatograms of the product A were in good agreement with those of authentic methyl lithocholate, indicating that the complex can also attack the ring A from α-side of the steroidal skeleton.
- 公益社団法人日本薬学会の論文
- 1977-05-25
著者
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
北海道大学 薬
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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