Further Studies on the Mechanism of the Color and Fluorescence Reaction of Testosterone with Sulfuric Acid
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概要
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The chemical structure of the chromo-and fluorophoric species χ-600 (λ_<max>=600nm, λ_<em>=615nm), which is formed in the reaction of testosterone (I) with sulfuric acid, was elucidated. The chemical species χ-600 was shown to be produced from the intermediary χ-300 (λ_<max>=300nm) through oxidation of its conjugate base (IV). 17-Methyl-18-norandrosta-4,6,8 (14), 13 (17)-tetraen-3-one (X), the conjugate base of χ-600,was isolated from the reaction of 17β-hydroxyandrosta-4,6-dien-3-one (VIII) with a mixture of selenic acid, sulfuric acid, and ethanol. The ^1H-nuclear magnetic resonance spectrum of X in 53% deuterio sulfuric acid indicated that χ-600 is a hydroxyalkatetraenyl cation (VII). On the basis of the results described above, a mechanism is proposed for the color and fluorescence reaction.
- 社団法人日本薬学会の論文
- 1982-10-25
著者
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三浦 敏明
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty of Pharmaceutical Sciences, Hokkaido University
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高木 英利
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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