Oxy-functionalization of Adamantane-1-acetic Acid and Adamantane-1-carboxylic Acid by the Ferrous Iron-Molecular Oxygen System in Aqueous Solution
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概要
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Oxygenation reactions of adamantanes with ferrous iron-molecular oxygen in phosphate buffer were investigated and the structures of the products were elucidated. In the reaction of adamantane-1-acetic acid (1a), five oxygenated products, the C (2)-oxo, C (4)-oxo, C (2), C (6)-dioxo, C (4)-ol, and C (3)-ol derivatives, were obtained. Similar oxygenation also occurred in the reaction of adamantane-1-carboxylic acid (2a) to give three products, the C (4)-oxo, C (4)-ol, and C (3)-ol derivatives. The oxy-functionalization of 1a and 2a in 0.5M phosphate buffer (pH 6.8) was found to occur almost quantitatively on addition of an appropriate amount of ferrous iron.
- 社団法人日本薬学会の論文
- 1982-01-25
著者
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柴田 邦彦
Faculty Of Pharmaceutical Sciences Hokkaido University
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三浦 敏明
Faculty Of Pharmaceutical Sciences Hokkaido University
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木村 道也
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
Faculty of Pharmaceutical Sciences, Hokkaido University
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沢谷 拓治
北海道大学 薬
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木村 道也
Faculty Of Pharmaceutical Sciences Hokkaido University
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