Detection of Biomarkers for Apoptosis in Rat Liver after Perfusion with 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1)

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概要

• 論文の詳細を見る

• We previously demonstrated that 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1) induced apoptosis in primary cultured rat hepatocytes. In this study, we investigated apoptotic biomarkers in rat liver after perfusion with 30μM Trp-P-1 as preliminary experiments for in vivo study. Induction of c-Myc and p53 protein and the activities of caspase-3,-6,and -8 were detected in Trp-P-1-perfused liver. In addition, Trp-P-1 modulated the DNA binding activity of the apoptosisrelated transcription factors, NF-kB and AP-1. These results imply a possibility that Trp-P-1 would induce apoptosis in vivo.

• 社団法人日本農芸化学会の論文
• 2000-09-23

著者

• HASHIMOTO Takashi

  Department of Biochemistry, Shinshu University School of Medicine

• ASHIDA Hitoshi

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

• Kanazawa K

  Laboratory Of Food And Nutritional Chemistry Graduate School Of Agriculture Kobe University

• Kanazawa Kazuki

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Kanazawa Kazuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University

• DANNO Gen-ichi

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• DANNO Genichi

  Department of Life Science, Graduate School of Science and Technology, Kobe University

• KIHARA Kaori

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• SHIOTANI Bunsyo

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• Kihara Kaori

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Kanazawa K

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Kanazawa Kazuki

  Department Of Biosystems Science Graduate School Of Agricultural Science Kobe University

• Ashida H

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Ashida Hitoshi

  Department Of Utilization Of Biological Resources Kobe University

• Ashida Hitoshi

  Department Of Agricultural Chemistry Kobe University

• Ashida Hitoshi

  Graduate School Of Science & Technology Division Of Life Science Kobe University

• Hashimoto T

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Ashida Hitoshi

  Department Of Life Science Graduate School Of Science And Technology Kobe University

• Ashida Hitoshi

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University:research Center

• Ashida Hitoshi

  Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.

• Danno G

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Hashimoto T

  Graduate School Of Agricultural Sci. Kobe Univ.

• Shiotani Bunsyo

  Division Of Life Science Graduate School Of Science And Technology Kobe University

• Hashimoto Takashi

  Department Of Biochemistry Shinshu University School Of Medicine

• Hashimoto Takashi

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

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