Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation
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概要
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Artemisia princeps is a familiar plant as a food substance and medicinal herb. In this study, we evaluated the effects of an ethanol extract of A. princeps (APE) on glucose uptake in differentiated L6 muscle cells. Treatment with APE elevated deoxyglucose uptake, and translocation of the insulin-responsive glucose transporter (GLUT4) to the plasma membrane in L6 myotubes occurred. The PI3K inhibitor LY294002 attenuated glucose uptake induced by APE. Phosphorylation of the Ser473 residue of Akt was not observed, but phosphorylation of PI3K, Akt (Thr308), and atypical PKC was. In addition, APE stimulated phosphorylation of AMP-activated protein kinase (AMPK) at a level similar to 5′-amino-5-imidazolecarboxamide-riboside (AICAR). These results indicate that APE stimulates glucose uptake by inducing GLUT4 translocation, which is in part mediated by combination of the PI3K-dependent atypical PKC pathway and AMPK pathways.
- 社団法人 日本農芸化学会の論文
著者
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HASHIMOTO Takashi
Department of Biochemistry, Shinshu University School of Medicine
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ASHIDA Hitoshi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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Ueda Manabu
Department Of Physics
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YAMAMOTO Norio
Food Science Research Center, House Wellness Foods Corporation
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KAWABATA Kyuichi
Organization of Advanced Science and Technology, Kobe University
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SATO Takuya
Food Science Research Center, House Wellness Foods Corporation
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KAWASAKI Kengo
Food Science Research Center, House Wellness Foods Corporation
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