3-Amino-1, 4-dimethyl-5H-pyrido[4, 3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes

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A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 μM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 μM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases.
社団法人日本農芸化学会の論文
2004-04-23