Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-oxidative Drugs
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概要
- 論文の詳細を見る
A decrease in hepatic phosphoglucomutase activity was found after intraperitoneal doses to rats with pro-oxidative drugs ; carbon tetrachloride, ethanol, paraquat, phenobarbital, thiopental, 3-methylcholan-threne, benzo[a]pyrene, Trp-P-1, benzene, and polychlorinated biphenyl. When the drugs were given at half of their LD_<50> values, except ethanol, hepatic phosphoglucomutase activities were decreased, and aldehydes which were detected by the thiobarbituric acid test were simultaneously accumulated 24 h after administration, in the liver. A significant correlation between phosphoglucomutase activity and the accumulations of aldehydes was obtained (r=-0.536). No other changes in hepatic enzymes and metabolites were commonly observed. On the other hand, the low-molecular-weight aldehyde fraction in secondary products of linoleic acid decreased phosphoglucomutase activity in hepatocytes cultured with dexamethasone. It was concluded that aldehydes originating from endogenous lipid peroxidation decreased phosphoglucomutase activity in the liver, and the assay of hepatic phosphoglucomutase activity was useful as a marker of oxidative stress induced by pro-oxidative drugs.
- 社団法人日本農芸化学会の論文
- 1994-01-23
著者
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ASHIDA Hitoshi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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Kanazawa K
Laboratory Of Food And Nutritional Chemistry Graduate School Of Agriculture Kobe University
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Kanazawa Kazuki
Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.
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Kanazawa Kazuki
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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DANNO Gen-ichi
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
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Kanazawa K
Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.
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Kanazawa Kazuki
Department Of Biosystems Science Graduate School Of Agricultural Science Kobe University
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Ashida H
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Ashida Hitoshi
Department Of Utilization Of Biological Resources Kobe University
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Ashida Hitoshi
Department Of Agricultural Chemistry Kobe University
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Ashida Hitoshi
Graduate School Of Science & Technology Division Of Life Science Kobe University
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Ashida Hitoshi
Department Of Life Science Graduate School Of Science And Technology Kobe University
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Ashida Hitoshi
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University:research Center
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Ashida Hitoshi
Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.
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Danno G
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Danno Gen-ichi
Department Of Agricultural Chemistry Kobe University
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