Comparison of the Effects of Orally Administered Linoleic Acid, and Its Hydroperoxides and Secondary Autoxidation Products on Hepatic Lipid Metabolism in Rats(Food & Nutrition)

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概要

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• Linoleic acid, and its hydroperoxides and secondary autoxidation products were orally administered to rats (400 mg/rat). Their effects on hepatic lipid metabolism were examined. Linoleic acid reduced the activities of de novo synthesis of fatty acids and acetyl-CoA carboxylase. It decreased the CoASH level and caused the accumulation of long-chain acyl-CoA. Hydroperoxides changed the compositions of unsaturated fatty acids in the hepatic lipids and lowered the content of neutral lipids. Secondary products stimulated carnitine palmitoyltransferase and decreased the content of neutral lipids. They reduced the activities of de novo synthesis of fatty acids and acetyl-CoA carboxylase, and the levels of CoASH and acetyl-CoA. Thus, the effect of secondary products was apparently different from those of Linoleic acid and its hydroperoxides.

• 社団法人日本農芸化学会の論文
• 1988-08-23

著者

• Kanazawa Kazuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University

• Ashida H

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Ashida Hitoshi

  Department Of Utilization Of Biological Resources Kobe University

• Ashida Hitoshi

  Department Of Agricultural Chemistry Kobe University

• Ashida Hitoshi

  Graduate School Of Science & Technology Division Of Life Science Kobe University

• Ashida Hitoshi

  Department Of Life Science Graduate School Of Science And Technology Kobe University

• Ashida Hitoshi

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University:research Center

• Ashida Hitoshi

  Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.

• Natake M

  Kobe Univ. Kobe Jpn

• Natake Masato

  Department Of Agricultural Chemistry Faculty Of Agriculture The Graduate School Of Science And Techn

• Kanazawa K

  Kobe Univ. Kobe Jpn

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