Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liber of rats orally administered varying amounts of autoxidized linoleate.

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The effects of dietary pantethine levels on the contents and compositions of fatty acids and on the levels of lipid peroxides were investigated with rat liver and its S-9 fraction under administration of 0 (non), 0.2 (low dose), and 0.35ml (high dose) of autoxidized linoleate (AL) per 100g body weight of the rats per day for 5 days. AL having 800meq/kg of peroxide value (PV) and 1, 700meq/kg of carbonyl value (CV) was dosed to the rats of each group given drinking water containing 0mg% (deficient), 6.25mg% (adequate), and 125mg% pantethine (excess). In the pantethine-deficient and -adequate groups, the contents of fatty acids both in the liver homogenate and in the S-9 fraction were correspondingly decreased by increasing dose levels of AL, and the decrease was remarkable especially in the pantethine-deficient group, but was not significant in the pantethine-excess group even by a high dose of AL. Particularly, in the high dose of AL, the notable decreases of oleic acid (C18:1) contents in both the liver and the S-9 fraction were observed in rats of the pantethine-deficient and -adequate groups. The thiobarbituric acid (TBA) values in the liver homogenate and the S-9 fraction were increased correspondingly by increasing dose levels of AL, and the increases were repressed in the pantethine-excess group.
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