Decrease of the NADPH Level in Rat Liver on Oral Administration of Secondary Autoxidation Products of Linoleic Acid(Food & Nutrition)
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概要
- 論文の詳細を見る
The hepatotoxicity of orally administered secondary autoxidation products of linoleic acid was investigated, as compared with the administration of a saline solution and linoleic acid as controls. The de novo synthesis of fatty acids was strongly reduced in the secondary products group. The level of NADPH in the liver significantly decreased while that of NADH did not. The activities of glucose-6-phoshate dehydrogenase and phosphogluconate dehydrogenase apparently decreased. The activities of NAD^+ kinase and NAD^+ synthetase decreased and that of NAD^+ nucleosidase increased in the secondary products group. Therefore, the depletion of NADPH can be attributed to the inhibition of two metabolic systems (an NADPH-supplemental system, and a synthetic system of NADP and NAD), and resulted in the reduction of lipogenesis in the liver.
- 社団法人日本農芸化学会の論文
- 1987-11-23
著者
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Kanazawa Kazuki
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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Ashida H
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Ashida Hitoshi
Department Of Utilization Of Biological Resources Kobe University
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Ashida Hitoshi
Department Of Agricultural Chemistry Kobe University
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Ashida Hitoshi
Graduate School Of Science & Technology Division Of Life Science Kobe University
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Ashida Hitoshi
Department Of Life Science Graduate School Of Science And Technology Kobe University
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Ashida Hitoshi
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University:research Center
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Ashida Hitoshi
Res. Center For Food Safety And Security Graduate School Of Agricultural Sci. Kobe Univ.
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Natake M
Kobe Univ. Kobe Jpn
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Natake Masato
Department Of Agricultural Chemistry Faculty Of Agriculture The Graduate School Of Science And Techn
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Kanazawa K
Kobe Univ. Kobe Jpn
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