Desmutagenicity of a Dibenzofuran-quinone Derivative toward the Mutagenicity of Trp-P-2(Food & Nutrition)
スポンサーリンク
概要
- 論文の詳細を見る
2,6-Di-tert-butyl-8-hydroxy-dibenzofuran-1,4-quinone (BHDQ) is one of the oxidative derivatives of butylated hydroxyanisole. The suppressive effect of BHDQ on the mutagenicity of Trp-P-2 was investigated using Salmonella typhimurium TA 98. BHDQ (0.8 nmol) suppressed the mutagenicity of Trp-P-2 (0.2 nmol) by 30% in the presence of the S9 mix. The suppressive activity of BHDQ toward the mutagenicity of the activated metabolite of Trp-P-2, N-OH-Trp-P-2, in the absence of the S9 mix was 80%. The bio-antimutagenicity of BHDQ was also measured, but it was found to be negligible as compared to its desmutagenicity. The reaction of BHDQ with N-OH-Trp-P-2 re-produced Trp-P-2. It was considered that BHDQ should re-convert N-OH-Trp-P-2 to the original Trp-P-2, and therefore BHDQ should be a desmutagen.
- 1989-04-23
著者
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Ueno Naoto
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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Kanazawa Kazuki
Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.
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Kanazawa Kazuki
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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DANNO Gen-ichi
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
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MIZUNO Masashi
Division of Life Science, Graduate School of Science and Technology, Kobe University
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NATAKE Masato
Department of Agricultural Chemistry, Kobe University
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Kanazawa Kazuki
Department Of Biosystems Science Graduate School Of Agricultural Science Kobe University
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Ueno N
Laboratory Of Developmental Biology National Institute For Basic Biology
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Mizuno Masashi
Division Of Science Of Biological Resources The Graduate School Of Science And Technology
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Mizuno Masashi
Division Of Life Science Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Nagano Japan Radio Co. Ltd. Currently With Kyushu Institute Of Technology
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Mizuno M
Kobe Univ. Kobe Jpn
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TODA Masaya
Division of Science of Biological Resources, The Graduate School of Science and Technology
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Toda Masaya
Division Of Science Of Biological Resources The Graduate School Of Science And Technology
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Natake M
Kobe Univ. Kobe Jpn
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Natake Masato
Department Of Agricultural Chemistry Faculty Of Agriculture The Graduate School Of Science And Techn
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Danno G
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Danno Gen-ichi
Department Of Agricultural Chemistry Kobe University
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Mizuno M
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Morimoto M
Graduate School Of Science And Technology Kobe University
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Kanazawa K
Kobe Univ. Kobe Jpn
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Mizuno Masashi
Division Of Clinical Immunology Department Of Medicine Nagoya University Graduate School Of Medicine
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