Photolysis of a Mutagenic Biphenyldiquinone Derivative that Induces a Desmutagen to Trp-P-1 and Trp-P-2 (Food & Nutrition)

スポンサーリンク

概要

• 論文の詳細を見る

• The yellow mutagen, 3,3'-di-tert-butyl-biphenyldiquinone-(2,5,2',5'), which was formed from butylated hydroxyanisole when reacted with sodium nitrite under acidic conditions, was transformed into a red crystal by irradiation with sunlight in an ether solution. The Photolytic product was identified as 2,6-di-tert-butyl-8-hydrocy-dibenzofuran-1, 4-quinone from instrumental analyses. During the irradiation, two kinds of free radicals were detected by electron spin resonance spectroscopy. A photolytic reaction mechanism, in which radical showed potent desmutagenic activity to frameshift-type reverse mutations induced by Trp-P-1 and Trp-P-2 for a strain of salmonella typhimurium TA 98.

• 1988-09-23

著者

• Kanazawa Kazuki

  Dep. Of Agrobioscience Graduate School Of Agricultural Sci. Kobe Univ.

• Kanazawa Kazuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University

• DANNO Gen-ichi

  Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University

• MIZUNO Masashi

  Division of Life Science, Graduate School of Science and Technology, Kobe University

• NATAKE Masato

  Department of Agricultural Chemistry, Kobe University

• Kanazawa Kazuki

  Department Of Biosystems Science Graduate School Of Agricultural Science Kobe University

• Mizuno Masashi

  Division Of Science Of Biological Resources The Graduate School Of Science And Technology

• Mizuno Masashi

  Division Of Life Science Graduate School Of Science And Technology Kobe University

• Mizuno Masashi

  Graduate School Of Science And Technology Kobe University

• Mizuno Masashi

  Nagano Japan Radio Co. Ltd. Currently With Kyushu Institute Of Technology

• Mizuno M

  Kobe Univ. Kobe Jpn

• TODA Masaya

  Division of Science of Biological Resources, The Graduate School of Science and Technology

• Toda Masaya

  Division Of Science Of Biological Resources The Graduate School Of Science And Technology

• Natake M

  Kobe Univ. Kobe Jpn

• Natake Masato

  Department Of Agricultural Chemistry Faculty Of Agriculture The Graduate School Of Science And Techn

• Danno G

  Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University

• Danno Gen-ichi

  Department Of Agricultural Chemistry Kobe University

• TODA Masaya

  Department of Agricultural Chemistry, Faculty of Agriculture, Kobe University

• OHARA Akihiro

  Division of Science of Biological Resources, The Graduate School of Science and Technology, Kobe Uni

• Mizuno M

  Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.

• Morimoto M

  Graduate School Of Science And Technology Kobe University

• Ohara A

  Meijo Univ. Nagoya Jpn

• Kanazawa K

  Kobe Univ. Kobe Jpn

• Mizuno Masashi

  Division Of Clinical Immunology Department Of Medicine Nagoya University Graduate School Of Medicine

関連論文

• Absorption of Dietary Licorice Isoflavan Glabridin to Blood Circulation in Rats
• Effects of Combined Administration of Quercetin, Rutin, and Extract of White Radish Sprout Rich in Kaempferol Glycosides on the Metabolism in Rats
• Tea Catechin Suppresses Adipocyte Differentiation Accompanied by Down-regulation of PPARγ2 and C/EBPα in 3T3-L1 Cells
• 3-Amino-1, 4-dimethyl-5H-pyrido[4, 3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes
• Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice(Food & Nutrition Science)
• 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) Is Incorporated into Rat Splenocytes, Thymocytes, and Hepatocytes Through Monoamine Transporters and Induces Apoptosis(Food & Nutrition Science)
• Subsequent Products After Antioxidant Actions of β-Carotene and α-Tocopherol Have No Salmonella Mutagenicity(Food & Nutrition Science)
• Evoking Cytochrome P450 1A Activity Interferes with Apoptosis Induced by 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) in Rat Hepatocytes under the Ex Vivo System(Food & Nutrition Science)
• Dietary Antioxidants Fail in Protection against Oxidative Genetic Damage in In Vitro Evaluation
• Detection of Biomarkers for Apoptosis in Rat Liver after Perfusion with 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1)
• Cytochrome P4501A1-Inhibitory Action of Antimutagenic Anthraquinones in Medicinal Plants and the Structure-activity Relationship
• Tryptophan Pyrolysis Products, Trp-P-1 and Try-P-2 Induce Apoptosis in Primary Cultured Rat Hepatocytes
• Antimutagenicity of Flavones and Flavonols to Heterocyclic Amines by Specific and Strong Inhibition of the Cytochrome P450 1A Family
• Effects of Dietary Lipid Peroxidation Products on Hormonal Responses in Primary Cultured Hepatocytes of Rats
• Angiotensin I-Converting Enzyme Inhibitors from Peptic Hydrolyzate of Cottonseed Proteins
• Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-oxidative Drugs
• Relationship between Hepatic Phosphoglucomutase Activity and Oxidative Stress Caused by Dietary Products of Lipid Peroxidation(Food & Nutrition)
• Identifications of 9-Oxononanoic Acid and Hexanal in Liver of Rat Orally Administered with Secondary Autoxidation Products of Linoleic Acid
• Determination of Lipid Peroxide Contents in Rat Liver by a New Coloration Test
• The Induction of Lipid Peroxidation in Rat Liver by Oral Intake of 9-Oxononanoic Acid Contained in Autoxidized Linoleic Acid
• Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation
• Synergistic Effects of Food Colors on the Toxicity of 3-Amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in Primary Cultured Rat Hepatocytes
• Commercial-scale Preparation of Biofunctional Fucoxanthin from Waste Parts of Brown Sea Algae Laminalia japonica
• Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D
• An IIR ALE Based on Constrained FIR Filter
• The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
• In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells
• A formation mechanism for 8-hydroxy-2'-deoxyguanosine mediated by peroxidized 2'-deoxythymidine
• Change in the Amount of SDS-Insoluble Gluten by Oxidants during Breadmaking
• Relationship between Baking Quality and Proportion of SDS-Insoluble Gluten in Wheat Flour
• Partial Purification and Some Properties of Protease from Wheat Germ and Flour(Food & Nutrition)
• Molecular Size Distribution of Glutenin from Wheat Flour and the Polymerization of Proteins during Purification(Food & Nutrition)
• Herb Water-extracts Markedly Suppress the Mutagenicity of Trp-P-2(Food & Nutrition)
• Desmutagenicity of a Dibenzofuran-quinone Derivative toward the Mutagenicity of Trp-P-2(Food & Nutrition)
• Effect of the Water Soluble Fraction on the Viscoelasticity of Wheat Gluten
• Desmutagenic Effects of Sulfhydryl Compounds on a Mutagen Formed from Butylated Hydroxyanisole Reacted with Sodium Nitrite(Food & Nutrition)
• Photolysis of a Mutagenic Biphenyldiquinone Derivative that Induces a Desmutagen to Trp-P-1 and Trp-P-2 (Food & Nutrition)
• Some Analytical Observations of Autoxidation Products of Linoleic Acid and Their Thiobarbituric Acid Reactive Substances
• DNA-Breaking Action of 2-tert-Butyl-p-quinone
• Quantification and Localization of Fucoidan in Laminaria japonica Using a Novel Antibody
• A High Throughput Pipelined Architecture for Blind Adaptive Equalizer with Minimum Latency(Digital Signal Processing)
• SB-3-3 Semi-Blind Adaptive Equalizer for Adaptive Array Antenna
• Effects of Peroxidation Products of Linoleic Acid on Tryptophan-nicotinamide Metabolism in Rats
• Effect of Lipid Peroxidation Products on the Catabolic Fate of Nicotinamide in Rats(Food & Nutrition)
• Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition
• Synthesis and Evaluation of 1-Arylsulfony1-3-piperazinone Derivatives as Factor Xa Inhibitors^ IV. A Series of New Derivatives Containing a Spiro [5H-oxazolo [3, 2-a] pyrazine-2 (3H), 4'-piperidin] -5-one Skeleton
• Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor II. Substituent Effect on Biological Activities
• Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors^ V. A Series of New Derivatives Containing a Spiro [imidazo [1,2-a] pyrazine-2(3H),4'-piperidin]-5(1H)-one Scaffold
• Implication of the complement system in the induction of antiglomerular basement membrane glomerulonephritis in WKY rats
• Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors VI. A Series of New Derivatives Containing N,S- and N,SO_2-Spiro Acetal Scaffolds
• Boromycin, an Anti-HIV Antibiotic
• The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids
• Complement-Mediated Renal Injury: Mechanisms and Role of Membrane Regulators of Complement
• The Expression Profile of Lectin Differs from That of Seed Storage Proteins in Castanea crenata Trees
• Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation
• Quantification and Localization of Fucoidan in Laminaria japonica Using a Novel Antibody
• Contents of Anti-Tumor Polysaccharides in Certain Mushrooms and Their Immunomodulating Activities
• Preparation of Antibody against Antitumor β-Glucan in Grifola frondosa and Its Application
• Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice
• Comparison of the Effects of Orally Administered Linoleic Acid, and Its Hydroperoxides and Secondary Autoxidation Products on Hepatic Lipid Metabolism in Rats(Food & Nutrition)
• Decrease of the NADPH Level in Rat Liver on Oral Administration of Secondary Autoxidation Products of Linoleic Acid(Food & Nutrition)
• Arthroscopic findings in Maisonneuve fractures
• Comparison of Changes in Ethylene and Polyamines of Water Convolvulus and Chingensai Exposed to Chilling Stress
• Commercial-scale Preparation of Biofunctional Fucoxanthin from Waste Parts of Brown Sea Algae Laminalia japonica
• Xenobiotic Tolerance of Primary Cultured Hepatocytes in Rats Fed a High-Fat or High-Protein Diet
• Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liber of rats orally administered varying amounts of autoxidized linoleate.

もっと見る 閉じる

スポンサーリンク