The Induction of Lipid Peroxidation in Rat Liver by Oral Intake of 9-Oxononanoic Acid Contained in Autoxidized Linoleic Acid
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概要
- 論文の詳細を見る
A component in the autoxidation products of linoleic acid (LA) which induced the endogenous lipid peroxidation was searched for. Secondary autoxidation products (SP) of LA induced the production of thiobarbituric acid reactive substances (TEARS) in liver as well as the LA hydroperoxides stimulated. SP were separated chromatographically into some fractions which were administered orally to rats. One fraction composed mainly of 9-oxononanoic acid (9-ONA) markedly stimulated the TEARS production in liver. Authentic 9-ONA also increased the lipid peroxide level as determined by a new test, as well as the activities of glutathione peroxidase and reductase in liver. Thus, hepatic lipid peroxidation was induced by orally given 9-ONA which was present in the autoxidation products of LA.
- 社団法人 日本農芸化学会の論文
著者
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ASHIDA Hitoshi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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Kanazawa K
Laboratory Of Food And Nutritional Chemistry Graduate School Of Agriculture Kobe University
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Kanazawa Kazuki
Department Of Agricultural Chemistry Faculty Of Agriculture Kobe University
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DANNO Gen-ichi
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
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NATAKE Masato
Department of Agricultural Chemistry, Kobe University
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MINAMOTO Shinsuke
Department of Utilization of Biological Resources, Graduate School of Science and Technology, Kobe U
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Ashida Hitoshi
Department Of Agricultural Chemistry Kobe University
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Natake Masato
Department Of Agricultural Chemistry Faculty Of Agriculture The Graduate School Of Science And Techn
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Danno Gen-ichi
Department Of Agricultural Chemistry Kobe University
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ASHIDA Hitoshi
Department of Utilization of Biological Resources, Graduate School of Science and Technology
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MINAMOTO Shinsuke
Department of Utilization of Biological Resources, Graduate School of Science and Technology
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