Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition
スポンサーリンク
概要
- 論文の詳細を見る
Compounds containing an ethylenediamine structure in place of the piperazine ring of M55113 (1) and M55551 (2) were synthesized to investigate the effects of a piperazine moiety and evaluated for activity as factor Xa (FXa) inhibitors. Most such compounds, however, exhibited lower activity (1/10-1/100) than that of M55113 and M55551 as FXa inhibitors.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Miyazaki Yutaka
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Mizuno Masashi
Division Of Science Of Biological Resources The Graduate School Of Science And Technology
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Mizuno M
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Mizuno Masashi
Division Of Life Science Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Nagano Japan Radio Co. Ltd. Currently With Kyushu Institute Of Technology
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Okamoto A
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Mizuno M
Kobe Univ. Kobe Jpn
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NISHIDA Hidemitsu
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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MUKAIHIRA Takafumi
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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SHIMADA Hiroyasu
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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SUZUKI Kazuhiro
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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SAITOH Fumihiko
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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MIZUNO Masashi
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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MATSUSUE Tomokazu
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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OKAMOTO Atsushi
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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HOSAKA Yoshitaka
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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MATSUMOTO Miwa
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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OHNISHI Shuhei
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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MOCHIZUKI Hidenori
Discovery Research Center, Mochida Pharmaceutical Co., Ltd.
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Okamoto Atsushi
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Shimada Hiroyasu
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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SAITOH Fumihiko
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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NISHIDA Hidemitsu
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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MUKAIHIRA Takafumi
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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MATSUSUE Tomokazu
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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HOSAKA Yoshitaka
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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Miyazaki Y
Department Of Pharmacy. Tokyo Women's Medical University Medical Center East:department Of Phar
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Mizuno M
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Morimoto M
Graduate School Of Science And Technology Kobe University
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Saitoh F
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Hosaka Y
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Matsusue Tomokazu
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Nishida H
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Mochizuki Hidenori
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Mukaihira Takafumi
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Mizuno Masashi
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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Suzuki Kazuhiro
Discovery Research Center Mochida Pharmaceutical Co. Ltd.
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